Every December in the small town of Ponchatoula, Louisiana a wooden wishing box is placed in the park as a Christmas tradition. After a night out together, Maddie encourages her sister Faith to put a wish in the box – a wish to experience true love for the first time. Faith and Maddie are surprised the next day when she meets the very handsome and eligible Andrew. As Christmas nears, Faith begins to wonder if Andrew is really perfect for her, or if the wish is leading her to her best friend, Wyatt.
When new parents Alex and Penny retreat from the city and move into a place outside town, the stress and massive sleep-deprivation caused by their infant has both of them seeing things in the house that may or may not exist. Persistent sightings of a strange woman has each of them wondering if they are suffering from hallucinations, or if their new home holds a dark, supernatural presence. As their fragile grasp on reality spirals into delirium, Alex and Penny find themselves nearly helpless to deal with the horrific truth of what is really going in this house.
When terrorist action releases a secret government virus in the Houston Federal building, the employees become aggressive and homicidal. Federal officials quarantine the building to wipe out the infected and control the story, but a small group of uninfected are fighting to get out.